Assoc Scientist Bioscience

Associate Proteomics Scientist Location: Cambridge, MA

Duration: 12 months

Shift: 8 Am to 4 PM

Job Description We are seeking a highly motivated and talented scientist to join Companys Chemical Biology and Proteomics group within Discovery Sciences. As a contract Associate Scientist you will apply proteomics to advance drug discovery, with a fixed term of 12-months with potential opportunity for extension. You will have the opportunity to work with a team of cross-functional scientists and support the development of new and successful therapies for patients. If youre inspired by the possibilities of science to make a difference and ready to Client what you can do join us.

Chemical Biology (Cambridge, MA) The Discovery Sciences department develops and applies the latest technologies for target discovery, hit identification and lead optimisation across Companys key therapy areas. The contract Associate Scientist will work in the Chemical Biology and Proteomics group to leverage chemical tools and proteomics technologies to conduct cellular profiling and mechanistic studies to better understand protein targets and therapeutic agents and enable project progression towards the clinic.

Core Day-to-Day Responsibilities

• Mammalian Cell Culture: Routine maintenance and growth of a couple of cell lines throughout the week, including preparing, mixing components, and filtering media bottles.
• Protein Conjugation & Purification: Receiving recombinant antibodies from collaborators in Gaithersburg, Maryland, performing small-scale bioconjugation reactions, purifying, and characterizing them via UV spectroscopy.
• Proteomics Assays: Conducting cell-based proteomic sample prep (from whole-cell samples to protein samples), affinity enrichment assays, and running mass spectrometry-based proteomics to observe cell surface changes post-treatment.
• Data Analysis: Performing proteomic data analysis using specialized search software.

Major Responsibilities

• Design and execute discovery proteomic screens using mass spectrometry to support mechanistic studies, Client Client targets, and elucidate Client disease biology.
• Perform proximity biotinylation studies in cells, using established automated affinity purification workflows, and data independent acquisition (DIA) mass spectrometry methods.
• Generate protein conjugates and characterize protein labeling.
• Analyze and interpret experimental data using established bioinformatic pipelines.
• Maintain detailed and accurate electronic laboratory notebooks.
• Generate and communicate cohesive scientific reports and participate in meetings within a cross-functional team.

Required Qualifications & Experience

• Bachelors or Masters in Chemical Biology, Biological Sciences or related field, with 1 3 years of scientific experience.
• Candidate must be self-motivated with a desire to learn, and an ability to effectively work both collaboratively and independently.

Preferred Background

• Exposure to mammalian cell culture.
• Experience interpreting and/or generating scientific figures.
• Hands-on experience processing proteomics samples is a plus.