Associate Research Scientist – Formulation

Associate Research Scientist – RNAi Formulations

Location: Lexington, MA

Work Schedule: Monday–Friday, 8:00 AM–5:00 PM

Work Arrangement: Onsite

Duration: 1 year

Pay Rate : $39/hr on w2

We are seeking an Associate Research Scientist – RNAi Formulations to join a multidisciplinary research team focused on non-viral delivery and formulation development for RNAi and oligonucleotide therapeutics.

This is a hands-on laboratory role focused on formulation preparation, analytical and biophysical characterization, developability assessments, troubleshooting, and stability evaluation of oligonucleotide formulations for injectable therapeutics.

Key Responsibilities

• Develop and characterize preclinical RNAi and oligonucleotide formulations across portfolio and platform projects.
• Perform hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis .
• Develop and execute screening assays to evaluate formulation performance and developability.
• Assess critical formulation properties including solubility, viscosity, osmolality, stability, degradation, and aggregation .
• Support formulation optimization using high-throughput screening and Design of Experiments (DoE) approaches where applicable.
• Conduct long-term storage and stability studies for RNAi conjugates and oligonucleotide formulations.
• Troubleshoot formulation and characterization challenges, identify technical gaps, and propose practical solutions.
• Maintain accurate experimental documentation and communicate results through technical summaries, reports, and presentations.
• Collaborate with cross-functional teams in non-viral delivery, formulation, oligonucleotide chemistry, bioanalysis, PK, CMC, and related functions .
• Support project deliverables and timelines in a fast-paced, multidisciplinary research environment.

Required Qualifications

• MS with approximately 3 years of relevant experience , or PhD with 1–3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related field.
• Hands-on experience with oligonucleotide or antibody/protein formulation and characterization is strongly preferred.
• Experience with analytical methods or assessments involving solubility, viscosity, osmolality, aggregation, stability, degradation, or other developability parameters .
• Strong hands-on laboratory skills with the ability to troubleshoot formulation and characterization challenges .
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent written and verbal communication skills and the