Associate Scientist I, Small Scale Synthesis

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead is seeking an Associate Scientist I to join the Discovery Chemistry department, focusing primarily on oligonucleotide synthesis, purification, and analytical chemistry in support of specific program goals. The role contributes to the success of Arrowhead's programs as part of a collaborative team of scientists.

Responsibilities

• Perform synthesis, purification, and analysis of oligonucleotides.
• Maintain a well-documented laboratory notebook.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
• Manage time effectively to meet deadlines.
• Adhere to safe laboratory practices.
• Assist with maintenance of bioconjugate and oligonucleotide inventory

Requirements

• B.S. in Chemistry or Biochemistry, with an excellent understanding of organic and analytical chemistry; or equivalent.
• Relevant experience working in a chemistry laboratory.
• Experience with a wide range of analytical techniques, especially HPLC.
• Ability to quickly learn new procedures and techniques.

Preferred

• Experience with large-molecule synthetic targets (especially oligonucleotides), in an academic or industry setting.
• Previous experience in a pharmaceutical setting.

Wisconsin pay range: $60,000 USD - $68,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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