Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI &amp; San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The Associate Scientist III in the Process Development Chemistry Group focusing on oligonucleotide analysis and synthesis development. This is an ideal position for an individual with an organic or biological chemistry background who has an interest in projects related to novel technology in synthesis and purification of oligonucleotides and bioconjugates.
Responsibilities
<ul>
<li>Independently provide accurate analytical results in support of new and on-going projects with a focus on process characterization.</li>
<li>Perform analytical techniques, such as HPLC, UV/Vis, LC/MS, etc.</li>
<li>Handle, analyze and characterize chemicals, pharmaceuticals, and related organic molecules.</li>
<li>Analyze data/results and interpret outcome of experiments and independently propose appropriate follow-up.</li>
<li>Calibrate, maintain, and troubleshoot all analytical equipment.</li>
<li>Work closely with senior chemists on development of new synthetic approaches to desired compounds with an eye toward large-scale synthesis</li>
<li>Cooperate with other chemists in the group in preparation of complex organic constructs</li>
<li>Analyze small-molecule and macromolecular targets using standard methods</li>
<li>Maintain a well-documented laboratory notebook</li>
<li>Prepare documentation for transfer of new technologies to the Manufacturing group</li>
<li>Track progress against project timelines, generate regular status updates, and communicate progress and issues to management, including presentation of findings at team meetings</li>
<li>Coordinate delivery of materials both internally and externally</li>
</ul>
Requirements
<ul>
<li>BS or MS in chemistry or biochemistry with an excellent understanding of organic and analytical chemistry</li>
<li>At least 4 years of experience working in a chemistry laboratory setting</li>
<li>Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and cGMP policies and practices.</li>
<li>Ability to correctly analyze data/results and interpret outcome of experiments and to propose appropriate follow-up.</li>
<li>Excellent verbal and written communication skills</li>
<li>Strong problem-solving skills</li>
<li>Eagerness to learn new techniques</li>
<li>Experience with small-molecule and macromolecule analytical techniques (e.g., HPLC, UV-Vis spectrophotometry, mass spectrometry, NMR, etc.)</li>
</ul>
Preferred
<ul>
<li>Masters Degree</li>
<li>Minimum of 2 years of experience with HPLC, including troubleshooting.</li>
<li>Experience analyzing a variety of in-process samples in support of process characterization studies.</li>
<li>Basic familiarity with GLP/GMP regulations</li>
</ul>
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Associate Scientist III, CMC Process Development

Associate Scientist III, CMC Process Development

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