多肽/小分子设计

该职位来源于猎聘 优秀者可谈 小分子设计经验丰富，无多肽经验亦可 【Responsibilities】

• Lead the design and optimization of therapeutic peptides, peptide-drug conjugates (PDCs), and constrained macrocycles using structure-based and AI-driven approaches.
• Direct peptide sequence optimization to enhance potency, selectivity, and drug-like properties (e.g., stability, solubility, permeability, oral bioavailability).
• Conduct structure-activity relationship (SAR) studies to guide peptide optimization in collaboration with medicinal chemists, computational chemists and biologists.
• Utilize molecular modeling, docking, and pharmacophore analysis to predict peptide-target interactions and binding modes.
• Collaborate with synthetic chemists to guide peptide synthesis, and reaction optimization.
• Contribute to peptide drug discovery projects from hit identification to preclinical development.
• Present research findings and strategic recommendations in cross-functional team meetings.
• Apply expertise in small molecule drug design to enhance peptide therapeutic properties and cross-modality strategies. 【Qualifications】
• PhD in Medicinal Chemistry, Organic Chemistry, or related field with solid background in small-molecule synthesis and drug design; experience in peptide synthesis and peptide design is a strong plus. 2. 5-10 years of experience in drug discovery, with expertise in structure-based drug design (SBDD) and ligand optimization.
• Proficiency in drug design software (e.g., MOE, PyMol, Schrödinger, Discovery Studio, or similar).
• Experience with peptide or protein-ligand interaction principles is preferred.
• Strong problem-solving skills and ability to work in interdisciplinary teams.
• Excellent written and verbal English skills, capable of independently reading English literatures, drafting research reports and communicating in international technical meetings.