LC-MS/MS Operator

Job Description – LC-MS/MS Operator

1. Position Details

Job Title: LC-MS/MS Operator / AnalystDepartment: Quality Control Reports To: QC Manager Industry: Food Testing / Honey Testing / FMCG

2. Job Purpose

To operate, maintain, and troubleshoot the LC-MS/MS system and perform accurate analytical testing of samples in accordance with approved methods, SOPs, quality standards, and laboratory requirements.

3. Key Responsibilities

LC-MS/MS Operation

· Operate and monitor LC-MS/MS instruments as per approved SOPs and test methods.

· Perform instrument start-up, shutdown, tuning, calibration, and performance verification.

· Prepare mobile phases, standards, reagents, and samples.

· Carry out sample extraction, cleanup, dilution, and final preparation.

· Create and manage analytical sequences and sample batches.

· Monitor chromatograms, retention time, peak shape, ion ratios, and system suitability.

Method & Analytical Work

· Perform analysis for residues and contaminants such as:

o Antibiotics

o Pesticides

o Veterinary drug residues

o Adultration(SMR,TMR)

o Other chemical contaminants, as applicable

· Review analytical data and identify abnormal or out-of-specification results.

· Perform repeat analysis, investigation, and troubleshooting where required.

Quality & Documentation

· Maintain complete and accurate raw data, worksheets, logbooks, and analytical records.

· Follow GLP, GMP, ISO/IEC 17025, and applicable laboratory quality requirements.

· Ensure proper documentation of instrument calibration, maintenance, and breakdown records.

· Participate in method validation, verification, recovery studies, precision studies, and measurement uncertainty activities.

· Support internal audits, external audits, and regulatory inspections.

Instrument Maintenance

· Perform routine preventive maintenance of LC-MS/MS and associated equipment.

· Check pumps, autosampler, columns, source cleanliness, gas supply, and vacuum performance.

· Coordinate with service engineers for major maintenance and breakdowns.

· Maintain inventory of columns, solvents, standards, consumables, and spare parts.

4. Educational Qualification

B.Sc. / M.Sc. in Chemistry, Analytical Chemistry, Biotechnology, Food Technology.

5. Experience

· 2–5 years: LC-MS/MS Operator / Analyst

· Experience in an NABL-accredited laboratory will be preferred.

· Experience in food, honey, pharmaceutical, environmental, or residue testing is an advantage.

6. Required Technical Skills

· Hands-on knowledge of LC-MS/MS operation.

· Knowledge of HPLC/UHPLC systems.

· Understanding of MRM/SRM transitions.

· Knowledge of chromatographic integration and data processing.

· Experience with calibration curves and quantification.

· Knowledge of sample preparation techniques such as QuEChERS, SPE, and LLE.

· Understanding of method validation and verification.

· Knowledge of system suitability and QC sample requirements.

· Familiarity with laboratory software and instrument data systems.

7. Desired Personal Skills

· Attention to detail and accuracy.

· Good documentation practices.

· Analytical and troubleshooting skills.

· Ability to work independently and in a team.

· Good communication and reporting skills.

· Ability to handle multiple samples and meet testing timelines.

8. Key Performance Indicators (KPI)

· Number of samples analyzed within TAT.

· Accuracy and quality of analytical results.

· Instrument uptime and performance.

· Compliance with SOPs and quality requirements.

· Timely completion of documentation.

· Reduction in repeat analysis and analytical errors.

Pay: ₹30,000.48 - ₹40,000.24 per month

Benefits:

• Food provided

Work Location: In person