Master Thesis Project: Stability Study for AAV Viral Vectors

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What You'll Do The aim of this master thesis is to investigate the stability of adeno-associated virus (AAV) viral vectors with regards to their capsid and genome integrity under different storage conditions. Stability will be assessed using a range of orthogonal methods. The team are actively developing purification solutions for AAV, plasmids, and other viral vector entities used in both research and manufacturing. These vectors serve as delivery vehicles for DNA in cell and gene therapy applications. Our goal is to support customers by providing purification products that enable the production of high-purity viral vectors suitable for use as final drug substances. To ensure product quality, we utilize a comprehensive toolbox of analytical methods to assess parameters such as purity, concentration, and impurities. Accurate determination of AAV concentration during the purification process is critical. This thesis project will involve hands-on work of generating viral vector material in a start to finish process. Key is the use of analytical instruments and techniques for characterizing produced AAV material under variant storage conditions.

Who You Are

• Education in Molecular Biology/Biology/Biotechnology/Biochemistry/Chemistry in the level of master thesis work (Examensarbete). The thesis work would be 30 hp starting in January 2027.

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