Oligonucleotide Scientist II

Job Title: Scientist II - Oligonucleotide Discovery

Location: South San Francisco, California, United States

Workplace Type: On-site

Employment Type: Contract on W2

Contract Duration: 12 Months (Possible Extension)

Job Description

We are seeking a Scientist II to support an innovative research team focused on oligonucleotide therapeutics discovery . This role offers the opportunity to contribute to cutting-edge RNA-based drug discovery programs in a highly collaborative research environment.

The successful candidate will work alongside multidisciplinary scientists supporting therapeutic programs across neuroscience, oncology, and immunology while driving nucleic acid chemistry and oligonucleotide synthesis activities.

Responsibilities

• Perform automated oligonucleotide synthesis using oligo synthesizers.
• Purify and characterize oligonucleotides using HPLC and Mass Spectrometry.
• Troubleshoot synthesis processes and impurity profiling.
• Develop and optimize nucleic acid chemistry workflows.
• Support lead molecule scale-up synthesis for preclinical studies.
• Collaborate with cross-functional biology and chemistry teams.
• Maintain laboratory instrumentation including oligo synthesizers, HPLC systems, and desalting equipment.
• Analyze experimental data and support therapeutic candidate progression.
• Review scientific literature and propose innovative chemistry strategies.
• Maintain accurate laboratory documentation while meeting project timelines.

Required Qualifications

• BS or MS in Organic Chemistry or related scientific discipline.
• Hands-on experience with automated oligonucleotide synthesis.
• Experience with HPLC purification and Mass Spectrometry characterization.
• Knowledge of nucleic acid chemistry and oligonucleotide therapeutics.
• Strong analytical and troubleshooting skills.
• Excellent written and verbal communication skills.
• Ability to work independently and collaboratively in a fast-paced research environment.

Preferred Qualifications

• Industry experience in pharmaceutical or biotechnology R&D.
• Experience with RNAi therapeutics.
• Knowledge of siRNA, ASO, or other nucleic acid therapeutic modalities.
• Experience with oligonucleotide delivery technologies.
• Bio-conjugation or large molecule drug discovery experience.

Interview Process

• One Round Interview (30 Minutes)
• Local candidates attend onsite.
• Non-local candidates may interview virtually.