代谢物鉴定PI-DMPK(J10228)

该职位来源于猎聘 职责描述：

• Develop LC-UV-MS and/or LC/radio detection/MS methods for detection, identification and semi-quantitative analysis of metabolites. Mass balance experience is preferred. 开发LC-UV-MS和/或LC/radio detection/MS方法，用于检测、鉴定和半定量分析代谢物。物质平衡的经验优先考虑。
• Conduct metabolite detection, characterization experiments in liver microsomes, S9 fraction, hepatocytes, plasma, urine, bile and tissues. 在肝微粒体、S9组分、肝细胞、血浆、尿液、胆汁和组织中进行代谢物检测、表征实验。
• Provide data interpretation and generate metabolite profiling and identification reports for various drug metabolism and ADME studies. 为各种药物代谢和ADME研究提供数据解释并生成代谢物分析和鉴定报告。
• Generate study protocols for in vitro metabolism and in vivo ADME experiments based on needs for drug discovery, development and regulatory registration. 根据药物发现、开发和监管注册的需要，生成体外代谢和体内ADME实验的研究方案。
• Familiar with study related guidelines, SOPs, protocols and technical reports. Respond to client’s questions or QC findings timely to ensure the study are completed within the planned time frame.

熟悉项目相关的法规、SOPs、方案和技术报告。及时解答客户的疑问，QC相关的发现项，确保项目在计划的时间表内完成。

• Assist in instrument maintenance to support the project need. 协助维护仪器设备，以满足项目的检测需求。
• Complying with EH&S policy. Maintain tidy in their workplace; Use personal protective equipment properly. 遵守安全守则。维持工作区域的清洁。试验中合理的使用个人防护设备。 任职要求： 药物代谢、药代动力学、有机化学等相关领域博士或硕士学位，3-5年相关工作经验。药物代谢、酶学和/或小分子和大分子结构阐明方面的工作知识。具有使用和维护液相色谱-高分辨质谱的实际经验，进行生物样品中小分子代谢物鉴定的经验，具备大分子表征的能力是加分项。良好的英语口语和写作技巧。