Principal Engineer, Site Reliability

The actual location of this job is in Bend, Oregon (USA). Relocation assistance is available for eligible candidates and their families, if needed.

As the Principal Engineer, Site Reliability, you will play a critical role in supporting the reliable production of life-changing medicines. Working closely with Engineering and Maintenance teams, you will develop and drive reliability strategies that improve equipment performance, increase system uptime, and support safe, compliant manufacturing operations.

This is a fully site-based role. Working together in person supports close, real-time collaboration and the technical precision needed to manufacture medicines to the highest quality and safety standards.

What you will get

• An agile career and dynamic working culture.
• An inclusive and ethical workplace.
• Compensation programs that recognize high performance.
• Participation in the Lonza bonus program, rewarding company and individual success.
• Comprehensive medical, dental, vision, life, and disability insurance from day one.
• A competitive 401(k) program with company matching contributions.
• Opportunities to work with advanced biomanufacturing technologies and grow through cross-functional collaboration.

What you will do

• Develop and lead reliability strategies that improve asset performance, equipment uptime, and operational efficiency.
• Partner with Manufacturing, Engineering, and Maintenance teams to support site goals and regulatory compliance.
• Lead root cause investigations and reliability improvement initiatives to prevent recurring equipment failures.
• Analyze maintenance and asset performance data to identify trends and improve reliability programs.
• Optimize asset criticality assessments and spare parts strategies to support business continuity.
• Establish and monitor reliability and maintenance KPIs and communicate results to senior leadership.
• Support audits, continuous improvement activities, and new equipment projects to ensure long-term reliability and maintainability.

What we are looking for

• Significant experience in reliability, maintenance, engineering, manufacturing, or operations environments.
• Experience leading complex projects and collaborating with cross-functional teams.
• Strong knowledge of mechanical and electrical systems and equipment reliability practices.
• Experience using maintenance management and asset performance systems to support decision-making.
• Knowledge of cGMP environments, engineering standards, and maintenance best practices.
• Strong problem-solving, analytical, and communication skills.
• Ability to influence stakeholders and drive continuous improvement in a regulated manufacturing environment.

About Lonza

Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that's the kind of work we want to be part of.

Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we offer equal employment opportunities to all qualified applicants regardless of race, religion, color, national origin, sex, sexual orientation, gender identity, age, disability, veteran status, or any other characteristic protected by law. If you're ready to help turn our customers' breakthrough ideas into viable therapies, we look forward to welcoming you on board.

Ready to shape the future of life sciences? Apply now.