Research Assistant II

Position Summary The MDI2 Program (www.musculoskeletal.ai) at the Department of Orthopedic Surgery and Sports Medicine has an immediate opening for a motivated Research Assistant (RA). Under general supervision, the RA will contribute to several image processing and modeling projects to assist with clinical decision making in patients with musculoskeletal joint disorders. The central theme of the work is the development of automated, end-to-end tools for assessment of joint anatomy and function in 3D: reconstructing patient-specific bone models from clinical images, quantifying morphology to localize anatomical abnormality, simulating joint articulation across ranges of motion, and interpreting the results against normative data. These tools are intended to run without manual intervention, at cohort scale, and to be reliable enough that clinicians can act on their output which places a premium on methods that behave predictably across the full spectrum of anatomy encountered in practice, from normal through deformity.

Key Responsibilities

• According to prescribed protocols and assigned schedules, perform a variety of image analysis studies, utilizing standard laboratory/research equipment and software, recording and checking results for completeness and accuracy, and assists in troubleshooting procedures.
• Develop algorithms for end-to-end automatic 3D joint morphology assessment
• Use image segmentation techniques to generate 3D models from imaging data. Conduct 2D and 3D measurements to quantify different anatomical indices of the joints. Contribute to computational simulations (e.g. Finite Element, Statistical Shape Modeling) and analysis of simulation outputs.
• Conduct literature searches and reviews, compiling information for journals and suggesting uses for new techniques to the P.I.
• Coordinate research projects and manage the timing of several concurrent projects using project management skills and collaboration with staff.
• Assist in the process of data collection and analysis using varied instrumentation and software; provide proper documentation and organization to ensure integrity and organization of collected data.
• Apply basic statistical knowledge; understand, interpret, and describe complex data by preparing graphs and tables.
• Participate in the preparation, review, and submission of manuscripts and abstracts for publication.

Education Minimum Qualifications

• A Bachelors degree is required. Master’s degree is preferred.

Experience:

• Minimum of one year of relevant work experience is required.
• Strong foundation in analytical and computational geometry and in 3D rigid-body kinematics. For example, definition and construction of coordinate systems, spatial transformations matrices, and the properties and limitations of common rotation representations, together with an understanding of why anatomically referenced frames are a prerequisite for meaningful comparison between subjects.
• Expertise with Python is required.
• Experience working with medical images and/or 3D geometric data (e.g., volumetric images, surface meshes, point clouds) is required.
• Experience developing algorithms that perform reliably across a wide range of normal and pathological anatomies is preferred.
• Computer simulation of joint motion or multibody kinematics; finite element analysis is preferred.
• Basic knowledge of human musculoskeletal anatomy, biomechanics and pathology is preferred.
• Sound software practice (e.g., version control, testing, reproducible pipelines) and experience processing data at scale (e.g., batch or high-performance computing).
• Statistical methods for validation and reliability.
• Registration and correspondence methods (e.g., rigid and non-rigid registration, statistical shape modeling, landmark propagation).
• Experience with Generative AI and Large Vision Models is preferred.
• Experience generating 3D anatomical models from medical images (e.g., segmentation, surface and mesh processing) is preferred.

The posted pay range is Boston Children’s reasonable and good-faith expectation for this pay at the time of posting.

Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.