Research Associate I - ADRD

Job ID: req4723

Employee Type: exempt full-time

Division: Applied & Development Research Program

Facility: Frederick: Ft Detrick

Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

Program Description The In Vivo Evaluation Group, Biological Testing Branch (BTB) of the Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD) is establishing both in vitro and in vivo tumor lines from patient biopsies from DCTD sponsored clinical trials with the goal of developing models for NCI’s Patient Derived Models Repository (PDMR). The PDMR is a repository of patient-derived models that include in vivo tumor fragments, in vitro tumor lines (2D and 3D), cancer associated fibroblasts, and DNA/RNA isolates. The goal of the PDMR is to distribute well validated and highly characterized material to researchers worldwide. A secondary mission is to evaluate the efficacy of approved oncology drugs in combination or as single agents in a subset of rare and recalcitrant PDX tumor models. In addition to the above, the candidate may also be responsible for establishing, characterizing and propagating murine tumor models. As each model is developed and fully characterized, preclinical studies are performed to evaluate the efficacy of immuno-oncology agents, small molecule targeted therapies alone or in combination and other agents of interest to the program.

Key Roles/Responsibilities Implant biopsied tumor material derived from patients into mice/rats, monitor the mice/rats daily for tumor growth, measure tumors, harvest tumor tissue for the repository and provide tumor material to staff for the establishment of in vitro cultures, quality control, RNA and DNA preparation for sequencing

Update the patient-derived xenograft (PDX) tracking sheets and log experimental data into Studylog. The maintenance of proper records is critical as each patient sample will be passaged and expanded multiple times in NSG mice or in rats

Implant, establish and propagate murine tumor models

Perform drug toxicity and drug efficacy studies that require administration of test agents by multiple routes (IV, IP, PO, SC) on schedules varying from a single dose to multiple times per day for multiple days/weeks depending on the agents administered

Maintain a proper living environment for test animals

Aid in any other routine tasks as needed (tube labeling, sample deliveries/pick-ups, autoclaving instruments, etc.).

Occasional weekend work is required

Tasks are performed independently and initially will involve training and supervision

Basic Qualifications To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency

In addition to the education requirement, a minimum of two (2) years of related experience

Proficiency with Microsoft Windows and Microsoft Office

Demonstrated organizational skills and database management skills

Ability to maintain precise records

Ability to be flexible to meet changing needs

Ability to work in a fast-paced environment

Ability to work alone as well as part of a team

Good written and verbal communication skills

Ability to obtain and maintain a security clearance

Preferred Qualifications Candidates with these desired skills will be given preferential consideration:

Previous animal handling experience

Knowledge of basic necropsy techniques

Experience with IV, IP, PO, SC injections

Previous experience working under ABSL-2 conditions

JOB HAZARDS

This position is subject to working with or has the potential for exposure to animals(s) and/or animal material(s).

This position is subject to working with or has the potential for exposure to infectious material, requiring medical clearance and immunizations.

Commitment to Non-Discrimination

All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

Pay and Benefits

Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here

59,600.00 - 85,400.00 USD

The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data.

The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions