Research Associate IV

Position Summary Under the direction of the Principal Investigator (PI) or designee, the Research Associate IV designs and performs a variety of complex research experiments with a high degree of independence. This position will contribute significantly to the management of the research program and will be involved in multiple aspects of the research projects and lab maintenance activities.

Essential Functions

• Independently design and perform multiple complex laboratory experiments
• Identify and utilize all software relevant to experiment and equipment used
• Interpret data, form conclusions and decide on next steps with a high degree of independence
• Maintain accurate records, and record results according to established lab, sponsor and University protocol
• Review literature, publications and grants relevant to assigned projects
• Record results according to established lab, sponsor & university protocol
• Perform in-depth data analysis and/or mathematical computations
• Maintain a detailed lab notebook according to lab practice
• Compile and analyze data, and present in a format suitable for publication according to PI specifications
• Present findings at lab/group meetings and other forums
• Maintain laboratory supply levels and order as noted
• Manage laboratory equipment service contracts and coordinate maintenance on laboratory equipment.
• Prepare and label buffers, media, solutions, etc.
• Monitor and enforce all safety regulation and infection control standards
• Identify and write standard operation procedures in compliance to EHS regulation specific for the lab
• Train on IACUC, EHS, Radiation safety protocols
• Comply with all applicable state, federal university, and sponsor policies and agreements
• Manage daily operations of the laboratory, including lab personnel, procedures and projects
• Identify problems and challenges, propose resolutions, implement appropriate solutions
• Develop and implement new protocols and/or modify defined protocols, as necessary, and with the approval of the PI
• Prioritize and perform several tasks or procedures simultaneously with attention to detail
• Perform duties and experiments with independence
• Mentor and train lab personnel on proper lab conduct and techniques
• Manage laboratory spending in accordance with budget guidelines provided by PI or designee
• Assist with budget and/or operational aspects of grant and contract proposals
• Negotiate with vendors to optimize available resources
• Contribute independently to writing sections for manuscripts and grants
• Direct the activities of research support staff
• Perform other duties as required

Required Qualifications

• Bachelors degree in Biological or Natural Science and 5+ years of relevant research experience or a related Masters degree with 3+ years of relevant research experience.
• Knowledge of Microsoft Office products
• Strong ability to analyze complex visual data in a quantitative and objective manner
• Ability to work in a team environment

The focus of the Wolfe Laboratory is the development of genome editing tools, such as base editors and prime editors, to employ as new classes of therapeutics. The successful candidate would be a part of an interdisciplinary team of laboratory scientists, clinicians, and computational biologists that are working on therapeutics for a variety of neurological and neuromuscular disorders, as well as cancer. We are looking for a candidate that would be a key player in developing and characterizing novel genome editing systems that could serve as new therapeutics – with these reagents potentially being used in clinical trials.

Experience Required

• Basic molecular biology techniques (PCR, cloning, gel electrophoresis, plasmid purification).
• Mammalian Cell culture experience.

Experience Desired (not Required)

• Genome editing
• Illumina Sequencing library preparation
• Experience using mouse disease models

Major Responsibilities (in Addition To The Standard Set)

• Participate in the development and characterization of genome editing systems tailored to correct gene mutations common in certain patient populations or kill cancer cells.
• Participate in the application of these genome editing systems in relevant mouse disease models.
• Organize ordering and stocking of supplies and reagents for the laboratory.

Supervision Received Under the direction of the Principal Investigator, or designee

Supervision Exercised Supervise aides, technicians, and associates

Environmental Working Conditions Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens

The University of Massachusetts Chan Medical School welcomes all qualified applicants and complies with all state and federal anti-discrimination laws.