Planet Pharma

SUMMARY
Our client, a promising Biotech is Singapore’s national platform dedicated to advancing RNA-based therapeutics and transforming the development of next-generation medicines and vaccines. Their mission is to position Singapore as a globally recognized center of excellence for nucleic acid therapeutics research, clinical translation, and commercialization. They are currently looking for a Scientist/Senior Scientist, RNA Analytical Development with deep translational expertise in advancing the next generation of RNA-based therapeutics.
RESPONSIBILITIES
<ul>
<li>Conducts mid and full-scale Bioreactor runs as per the agreed and defined schedule</li>
<li>Develop and implement phase-appropriate analytical characterization strategies for raw materials (including novel lipids, targeting ligands, and pDNA), drug substances (such as mRNA, ASO, siRNA, and gRNA), and drug products (including LNPs and conjugated oligonucleotides).</li>
<li>Design and execute analytical workflows for RNA raw materials, drug substances, and drug products using orthogonal techniques, including HPLC, LC-MS, CE, UV spectroscopy, qPCR, DLS, and TEM, to support platform development and pipeline programs.</li>
<li>Apply Quality by Design (QbD) principles to identify critical quality attributes (CQAs) and ensure analytical methods are robust, scalable, and fit for phase-appropriate development and throughput requirements.</li>
<li>Collaborate closely with cross-functional teams to align analytical strategies with overall product development objectives and project timelines.</li>
<li>Develop, validate, and maintain analytical methods, SOPs, validation protocols, and supporting documentation in accordance with industry standards and regulatory requirements.</li>
<li>Maintain accurate and comprehensive analytical records within LIMS and ELN systems to ensure data integrity, traceability, and reproducibility.</li>
<li>Prepare and present technical reports, scientific summaries, and project updates for internal stakeholders and cross-functional teams.</li>
<li>Stay informed of emerging analytical technologies, scientific advancements, and regulatory developments relevant to RNA-based therapeutics and characterization.</li>
</ul>
QUALIFICATIONS
<ul>
<li>PhD in Analytical Chemistry, Pharmaceutical Sciences, or a related scientific discipline.</li>
<li>Minimum of 4+ years (Scientist) or 8+ years (Senior Scientist) of hands-on experience in analytical development for nucleic acid therapeutics within pharmaceutical or biotechnology environments.</li>
<li>Extensive experience with multiscale purification technologies, including preparative RP-HPLC, affinity chromatography, ion-exchange chromatography, hydrophobic interaction chromatography (HIC), size-exclusion chromatography (SEC), and tangential flow filtration (TFF), as well as the associated analytical instrumentation.</li>
<li>Strong expertise in a broad range of analytical techniques, including LC-MS, LC-HRMS, CE-SDS, DSC, HIC, and NMR, with proven experience developing analytical workflows for the comprehensive characterization of RNA raw materials, drug substances, and drug products.</li>
<li>Demonstrated hands-on experience developing and implementing LC-MS–based workflows for in-process monitoring and final quality control testing of modified oligonucleotides and ligand-oligonucleotide conjugates, including GalNAc, cholesterol, and fatty acid conjugates, to support multiple development programs.</li>
<li>Proven track record of establishing and optimizing automated, high-throughput analytical platforms to enable efficient process development and increase synthetic throughput.</li>
<li>Solid understanding of regulatory requirements for analytical method validation and CMC documentation, with experience supporting IND-enabling programs highly preferred.</li>
<li>Collaborative and dependable team player with the ability to work effectively across cross-functional teams while demonstrating the independence, initiative, and accountability needed to achieve scientific and operational objectives.</li>
<li>Strong problem-solving skills, with a proven ability to troubleshoot complex technical challenges and adapt to changing priorities in a fast-paced, quality-driven environment.</li>
<li>Excellent organizational, interpersonal, and written and verbal communication skills, with the ability to present complex scientific concepts clearly to diverse audiences.</li>
</ul>
DURATION
Permanent, full-time
LOCATION
Singapore (Relocation and Visa supported)
ABOUT PLANET PHARMA
Planet Pharma is an American parented Employment Business/Agency that provides global staffing services with its head-quarters in Chicago and our EMEA regional office located in Central London. We have invested significantly in creating a robust international platform that enables us to work compliantly in 30+ countries with a current network of 2500+ active contractors globally as well as a very strong permanent / direct hire recruitment offering.
Our specialist knowledge and close relationships with our clients and the wider industry really makes us unique in our field. Just recently we were recognised by FORBES as the 17th best professional staffing firm, and have won multiple awards from industry accredited bodies for our commitment to excellence and service delivery. We have extensive functional expertise including: Regulatory Affairs, Pharmacovigilance, QA, QC, Submissions experts, Clinical development, Quality, Biostatistics, and Medical Affairs / Writing.
We are an equal opportunities Recruitment Business and Agency. We welcome applications from all suitably qualified candidates regardless of their race, sex, disability, religion/belief, sexual orientation or age.
<a href="http://www.planet-pharma.com" rel="nofollow noopener" target="_blank">www.planet-pharma.com</a>
TO APPLY
Please click ‘apply’ or contact Steven Fan (Recruiter, APAC) at Planet Pharma for more information:
E:
<a href="mailto:steven.fan@planet-pharma.com" rel="nofollow noopener" target="_blank">steven.fan@planet-pharma.com</a>
T:
: +61 370427282
Linkedin:
<a href="https://www.linkedin.com/in/steven-fan-38a394128/" rel="nofollow noopener" target="_blank">https://www.linkedin.com/in/steven-fan-38a394128/</a>

Scientist/Senior Scientist, RNA Analytical Development(Relocation /Visa Support Provided)

Scientist/Senior Scientist, RNA Analytical Development(Relocation /Visa Support Provided)

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