Scientist/Sr Scientist, DEL Selection

New Haven, CT | On-Site

Our client, a Venture-backed biotechnology company developing next-generation small molecule therapeutics is seeking a Scientist, DEL Selections to lead and execute DNA-Encoded Library (DEL) screening campaigns supporting drug discovery programs. This is a highly visible, hands-on role partnering with biology, chemistry, and computational teams to identify and validate novel small molecule hits and advance programs from hit discovery through lead optimization.

Key Responsibilities

• Design and execute DEL selection campaigns and protein capture assays
• Build and maintain internal DEL screening capabilities, from assay setup through NGS sample preparation
• Collaborate cross-functionally to develop data-driven screening strategies
• Analyze and interpret DEL datasets to drive hit identification and validation
• Present scientific findings and recommendations to project teams and leadership
• Support compound characterization through biophysical and biochemical assays (e.g., SPR, TR-FRET)

Qualifications

• PhD with postdoctoral training and 3-5+ years of industry experience, or BS/MS with significant relevant experience
• Deep expertise in DNA-Encoded Library (DEL) screening, sample preparation, and data analysis
• Proven ability to independently drive multiple drug discovery campaigns
• Strong understanding of hit identification and validation workflows
• Experience with biophysical assay platforms is a plus
• Ability to thrive in a fast-paced, collaborative biotech environment